Pathway-GPS and SIGORA: identifying relevant pathways based on the over-representation of their gene-pair signatures.

At the same time, SIGORA avoids a few biologically implausible pathways that are considered highly significant by at least two other methods: e.g., “Staphylococcus aureus infection” (a bacterial infection) is the most significant pathway in InnateDB’s results, and the second highest ranked pathway in gProfileR’s results, but is not significant in SIGORA’s results.

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