Expression of RTEs and satellite sequences increases with age HDF passaged to replicative senescence in cell culture also show an overall trend of increasing hetero-chromatin and decreasing gene activity, but in addition display more complex changes such as relaxation of constitutive heterochromatin in gene poor regions and centromeres [ 25 ].
← all excerpts
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues.
1
—
—