Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.

Concerning the circadian amplitude composed of the difference between peak and nadir of the circadian gene expression we detected a highly significant damping in the cycling expression of the three clock core components BMAL1, PER1 and PER2 between the two study groups in the first period and in case of BMAL1 also in the second period ( Figure 3 ).

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