Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis.

The findings were overall similar to those registered when normalizing to RNaseP, but difference between progressors/nonprogressors was now borderline significant (p = 0.08), and the difference in mean telomere length between diploid and aneuploid lesions within the progressors was statistically significant (p = 0.04) (see Additional file 2 ).

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One major finding is a highly significant increase in number of ultra-short telomeres in progressor colons compared to nonprogressor colons, both when including all lesions of the progressors as well as when restricting the progressor lesions to non-dysplastic, diploid lesions only.

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