Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells.

Of interest, within the panel of cytokines and chemokines detectable at the plasma level, 12 (MIP-1 α , IL-8, TNF- α , GM-CSF, IFN- α 2, MIP-1 β , VEGF, EGF, Eotaxin, MCP-1, PDGF, and RANTES) were significantly ( P < 0.05) increased in CVD patients compared to healthy controls while 2 additional cytokines (G-CSF and CXCL10) showed levels close to significance ( Table 1 ).

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