Do Lin−/Sca1+ Cell Levels Respond to Stroke? Analysis of the ability of Lin−/Sca1+ cells to mobilize from the bone marrow to the peripheral blood following stroke ( Figure 1 ) demonstrate that, following murine stroke, bone marrow production of Lin−/Sca1+ cells was minimal at 4 hours (106±46% versus sham), but achieved a highly significant increase by 24 hours (272±60% versus sham).
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SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
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Serum SDF1-A levels did not achieve significance until 24 hours post stroke surgery ( Figure 2A ).