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Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma.

J Transl Med · 2014 · PMC3896773 · PMID 24418330

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an increasing trendno p-value reported
Recently, given that there has been an increasing trend in the incidence of DLBCL, it is imperative to develop specific and effective treatments related to the pathogenesis of the disease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.