Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases.

The carrier status of at least one copy of COMT A_C_C_G haplotype determines low metabolic activity of COMT enzyme, and patients with at least one copy of A_C_C_G haplotype show better clinical outcome measured by ODI score, compared with non-carriers, who inherited a combination of G_C_G_G, A_T_C_A or A_T_G_G haplotypes (i.e., subjects without A_C_C_G haplotype), although the recorded improvement in ODI score was only borderline significant ( p = 0.079, Table 3 ).

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