The biological effect of large single doses: a possible role for non-targeted effects in cell inactivation.

A highly significant dose-dependent inhibition of colony formation (P<0.0001) was also found for MDA-MB-231 breast cancer cells with a similar maximum decrease of 24% (95% c.i.: 10–38) ( Figure 2b ).

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The decrease at 15 Gy relative to 5 and 10 Gy analysed together was significant (or borderline significant) for both breast cancer cell lines (P = 0.053 and 0.007, respectively).

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