Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes.

Although there was a nonsignificant trend of increased CoxIV activity (normalized to that of citrate synthase, an exclusive marker of the mitochondrial matrix) with addition of E2, the change was not statistically significant.

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This difference may be significant, considering the divergent functionality among the different members of the p38 MAPK family [8] , [32] , [33] .

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