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The effect of storage time and freeze-thaw cycles on the stability of serum samples.

Biochem Med (Zagreb) · 2013 · PMC3900085 · PMID 23457767

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an increasing trendno p-value reported
The estimated percentage change in uric acid concentrations per freeze thaw cycle showed an increasing trend over time as this analyte was demonstrated as unstable after 48 hours in human serum stored at −4 °C in a recent study ( 18 ).

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