Barely Significant
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Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide.

PLoS One · 2014 · PMC3901689 · PMID 24475175

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highly significantno p-value reported
The weight gain effect of PEG-SRLA during the one week treatment of control rats was highly significant, similarly to the effect seen in various mice strains [28] , [35] indicating similar reactivity at least in rodents.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.