Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

The C3 K155Q (position 133 excluding the signal peptide) variant demonstrated compelling evidence of association in replication ( p =3.5×10 −5 , OR =2.8) and was highly significant with a large effect size in joint analysis with discovery samples ( p =5.2×10 −9 , OR =3.8; Table 1 ).

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