The assessment and impact of sarcopenia in lung cancer: a systematic literature review.

Three studies explored the loss of muscle mass comparing men and women, finding that a significantly greater percentage of men were affected, 25 64 and that they exhibited a decreasing trend in FFM after chemotherapy compared with baseline, whereas women did not. 29 Reflecting the process of loss of muscle mass in the different stages of cancer, a study of 60 patients with preoperative NSCLC with stage I and II disease showed no difference in FFM compared with controls, 27 whereas in a cohort of 352 patients with advanced cancer, 84% of those with cachexia had a reduced FFM. 74 The pathophysiology of loss of muscle mass in patients with lung cancer is complex, as illustrated in the diversity of articles exploring this.

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