PGBD5, like other piggyBac elements, belongs to the RNase H clan of Pfam structures (pfam.sanger.ac.uk), and exhibits a highly significant match (1.7e-80) to the Hidden Markov Model for eubacterial and archaeal IS4 transposases [ 20 ].
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PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans.
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