REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer.

Supporting the direct role of REST in mediating the repression of some of these genes is the finding that regulatory regions of 78 of the genes induced by siREST in LNCaP cells have been shown to contain REST binding sites by ChIP sequencing analysis ( 40 ), an overlap that is highly significant (FDR < 0.001) by gene set enrichment analysis ( 41 ) ( Supplementary Figure S2 ).

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