highly significantP < 1.00e-3
Statistical analyses were performed using a two-tail Fisher-exact test: P -values ≤ 5.00e-2 (a = 0.05) were taken to be significant (1.00e-2 ≤ P ≤ 5.00e-2 * significant; 1.00e-3 ≤ P ≤ 1.00e-2 ** very significant; P < 1.00e-3 *** highly significant).