34 In young breast cancer cases (<40 years), locoregional control after breast-conserving surgery highlighted that the absence of CYP19-aromatase activity in removed tumor samples carried a highly significant risk for locoregional tumor recurrence. 35 In conclusion, TNBC in young patients is not a distinct entity with mysteriously unique etiology.
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Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implications.
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