Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients.

J Neurooncol · 2014 · PMC3905192 · PMID 24420923

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highly significantno p-value reported

In conclusion, the methylation levels at several individual CpGs sites or combinations of CpGs in the MGMT CpG island determined by PSQ—some of which were previously found to be correlated with MGMT expression—are highly significant predictive markers for GBM patients treated with the current standard care treatment.

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