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E. coli infection modulates the pharmacokinetics of oral enrofloxacin by targeting P-glycoprotein in small intestine and CYP450 3A in liver and kidney of broilers.

PLoS One · 2014 · PMC3909222 · PMID 24498193

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an increasing trendno p-value reported
coli infected broilers, though an increasing trend was observed.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.