highly significantP <4.1×10 –4
When combined with published data, 11 of the 15 loci showed highly significant evidence for association with schizophrenia ( P <4.1×10 –4 ).
3
0.0004
0.0740
The sentences
just fails to reach significanceP = 0.074
10 The finding of four individuals in the case group with deletions and none in the control group just fails to reach significance in our independent sample ( P = 0.074) but can be regarded as supportive independent confirmation.
14 To this list we added three loci: exon-disrupting deletions at the NRXN1 gene, as there is consensus that they increase risk for developing schizophrenia; 9 , 10 , 13 deletions at distal 16p11.2, the evidence for which was published after the above review; 18 and duplications at the WBS region, a locus that just failed to reach significance in that review, but received support in a subsequent study. 16 For duplications at the AS/PWS region, we tested their parental origin using a DNA methylation-sensitive high-resolution melting curve analysis, 29 as previous research suggested that the maternal ones are specifically implicated 6 (online supplement, section 5).