Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells.

This is highly significant because proliferation of antigen-specific CD8 + cells itself is dependent on the presence of GITR-L, as shown by in vitro experiments and by adoptive transfers into GITR-L −/− Rag −/− and Rag −/− mice that had received AAV8-OVA.

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