Powerful sequence similarity search methods and in-depth manual analyses can identify remote homologs in many apparently "orphan" viral proteins.

J Virol · 2014 · PMC3911697 · PMID 24155369

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closest p

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highly significantno p-value reported

The two groups had highly significant similarity (HHalign E value of 6 × 10 −14 ) between the regions corresponding to aa 27 to 175 of CBPV ORF3 and aa 50 to 194 of Negev virus ORF3, confirming the homology.

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