The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

45 Postmortem analysis of spleens and lymph nodes from individuals who succumbed to sepsis confirmed the highly significant loss of CD4 and CD8 T cells. 46 Memory CD8 T cells are highly susceptible to apoptosis in systemic inflammatory states such as septic shock and are depleted in sepsis. 49 These results indicate that depletion of adaptive immune cells is a major pathologic component of sepsis with potential debilitating effects on host immunity.

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