Endogenous RNA interference is driven by copy number.

Elife · 2014 · PMC3918874 · PMID 24520161

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highly significantno p-value reported

As observed for the GAL10 ncRNAs, the GAL10 mRNA was expressed at higher levels in the RNAi+ strain than in the wild-type ( Figure 8D compare lanes 1,2) but, nonetheless, both wild-type and RBSΔ high-copy GAL cluster plasmids caused highly significant >50% knockdowns of the GAL10 mRNA compared with the empty vector control ( Figure 8D lanes 2,4,6).

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