In this design, an LOD score of 2.2 is suggestive evidence for linkage (expected to occur once by chance in a genome scan), an LOD score greater than 3.6 represents significant linkage (expected to occur by chance with a probability of 5%), and an LOD score of 5.4 is highly significant (probability of chance occurrence is less than 0.1%) ( Lander and Kruglyak, 1995 ).
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