Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.

A subsequent comparison of the normalized mutant/wild-type ratios ( Figure 6D ) revealed a marginally significant difference (p<0.05) between P23K (0.37 ±0.10) and both D190N (0.64 ±0.18 SD) and P23Y (0.67 ±0.13 SD), but there were no significant differences in the GFP signal intensity between any of the other mutants.

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Carriers of mutations within the intradiscal region of rhodopsin ( Table 1 ) retain a highly significant correlation under the new analytical parameters (see Figure 2 , Table 2 ).

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