CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling.

While the placenta undoubtedly makes an important contribution to the plasma CX3CL1 concentration, synthesis of this chemokine by maternal blood mononuclear cells and other tissues is also likely to be significant, although the exact extent remains uncertain.

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