Angiopoietin-1 upregulates de novo expression of IL-1β and Il1-Ra, and the exclusive release of Il1-Ra from human neutrophils.

For instance, providing validation that the above targets might be significant is a recent finding that, when stimulated with Ang1 for 2 or more hours, neutrophils increased their IL-8 de novo synthesis [12] , an effect that did not extend to Ang2.

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