Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset.

Second, after cyclin E1 levels plateaued, they dropped slowly during the final half of S phase ( Figure 5D ); this also occurred concomitant with a decreasing trend of cyclin E1 mRNA.

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This is consistent with an increasing trend in cyclin E1 transcription that occurred up to 24 h during the time course in Cdh1-ablated cell populations ( Figure 2D ).

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