Multiple lines of evidence triangulated to Col17a1 : 1) mapping in two F 2 crosses (DBA1 × 129X1- Lamc2 jeb/jeb F 2 and B6 × FVB- Lamc2 jeb/jeb F 2 ) identified a strong QTL overlapping the Col17a1 locus; 2) phenotype to Col17a1 genotype correlations of F 2 mice of the most polarized strain backgrounds (MRL and FVB) were highly significant; 3) phenotypic analysis of chr19 congenics and sub-congenics consistently framed Col17a1 as the modifier locus.
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Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice.
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