The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

1 B and 2 , D and E ), the finding of hepatic steatosis in some children with CMRD ( 16 , 17 , 91 ), the highly significant positive correlations between SAR1B , APOB , and MTTP mRNA in human liver samples, and the finding that partial Sar1b knockdown reduced Srebp2 processing ( Fig. 6 H ) paired with the expected corresponding reduction in levels of mRNAs encoding enzymes active in cholesterol biosynthesis ( Fig. 4 C ).

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