Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.

EMBO Mol Med · 2014 · PMC3927959 · PMID 24375627

Europe PMC DOI

hedged sentence

0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

failed to reach significanceP = 0.089so close (0.05 < p ≤ 0.1)

The proportion of committed neuronal cells had a tendency to be higher in neurospheres derived from Twin-DS-iPSCs but failed to reach significance (5.6 ± 0.9 versus 14.7 ± 3.6%, P = 0.089 for β3-TUBULIN + cells in neurospheres derived from Twin-N-iPSCs and Twin-DS-iPSCs, respectively; supplementary Fig S5B).

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