Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics.

The primary efficacy analysis (October 2009) showed a nonsignificant trend toward increased median overall survival (OS) with decitabine (7.7 months; 95% confidence interval [CI]: 6.2–9.2 months) versus TC (5.0 months; 95% CI: 4.3–6.3 months), with an estimated hazard ratio (HR) of 0.85 (p = 0.108).

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