The concentration values of drug versus time, for free emtricitabine and emtricitabine NPs, were subjected to two-tailed unpaired t -test and the P values (*** P < 0.001) indicated extremely significant difference. 4.
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Optimization (central composite design) and validation of HPLC method for investigation of emtricitabine loaded poly(lactic-co-glycolic acid) nanoparticles: in vitro drug release and in vivo pharmacokinetic studies.
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