Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.

In conclusion, despite our cohort having an average individual IVM intake of 1.5, highly significant associations with the region or frequency of MDA within the community suggest that a lowered infection pressure due to IVM MDA may affect community members that have not regularly participated in MDA programmes, implying that immune responses are affected by the number of times an individual had received IVM and the amount of MDA therapy on a community level.

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