DLN, serum viremia and spleen All of the attenuated viruses (groups 2 and 3) exhibited a highly significant inability to amplify within the DLN ( Fig. 8D ), suggesting a reduced or delayed spread either within the lymphatic vessels to the DLN or within the organ itself.
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Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.
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