Intriguingly, SUMO-1 is conjugated to K6 and K9 equivalently in the absence of other modifications, whereas phosphomimetic substitutions of S13 and S16 appear to block SUMO modification on K9 or promote SUMO-1 modification on K6, which may be significant to regulation of other HTT modifications, such as K9 acetylation.
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SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.
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