highly significantP <2.2 × 10 −16
Visually, H3K4me2 also seemed to be lost at this region, but the major site of enrichment, at the spacer promoter, was unaffected, and the locus-wide correlation remained robust and highly significant (mESC vs. mNPC: R 2 = 0.87, P <2.2 × 10 −16 ).