Myc and max genome-wide binding sites analysis links the Myc regulatory network with the polycomb and the core pluripotency networks in mouse embryonic stem cells.

Approximately 50% of newly identified Myc binding sites by Bio-Myc ChIP-Seq overlap with NMyc targets and the newly identified Myc bound regions show enrichment in motif sequence corresponding to the perfect Myc E-Box with a definitely significant p-value (1E-142) ( Figure 4D ).

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