Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet).

After 21 days, NiNPs caused a robust and highly significant increase in mucous cell metaplasia in T-bet -/- mice, while WT mice exposed to NiNPs showed only a slight increase in mucous cell metaplasia that was not statistically significant (Figure 1 A).

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