Targeted recombinant fusion proteins of IFNγ and mimetic IFNγ with PDGFβR bicyclic peptide inhibits liver fibrogenesis in vivo.

PLoS One · 2014 · PMC3933682 · PMID 24587093

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highly significantno p-value reported

Two subsequent intravenous injections of IFNγ, BiPPB-IFNγ or BiPPB-mimIFNγ led to the highly significant reduction in collagen I expression (major extracellular matrix protein) and α-SMA (HSC activation marker) expression.

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