TRF1 showed a slight trend toward increasing α factor from 0.65 to 0.89 with increasing ionic strength ( Supplementary Figure S4C and Table 1 ); this result suggests pausing at low ionic strength, which is abrogated by salt.
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TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres.
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