Combination therapy with ampicillin and azithromycin in an experimental pneumococcal pneumonia is bactericidal and effective in down regulating inflammation in mice.

J Inflamm (Lond) · 2014 · PMC3936873 · PMID 24565171

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an increasing trendno p-value reported

Moreover an increasing trend in multidrug resistance (such as β-lactams, macrolides, doxycycline, and recently fluoroquinolone antibiotics) among these penicillin resistant SP has been a major concern worldwide for clinicians and has complicated the management of CAP [ 7 , 8 ].

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