highly significantP <2×10 −16
The association between miR-100 and EMT markers was further validated in human tumors: from the Cancer Genome Atlas (TCGA) breast cancer data [17] , we observed a moderate but significant inverse correlation between miR-100 and E-cadherin expression levels ( Rs = −0.1, P = 0.006, Figure 1F ) and a highly significant positive correlation between miR-100 and vimentin expression levels ( Rs = 0.43, P <2×10 −16 , Figure 1G ). miR-100 suppresses tumor growth and is downregulated in human breast cancer We performed TCGA data analysis to determine the expression levels of miR-100 and miR-22 in human breast cancer.