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Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.

PLoS One · 2014 · PMC3937388 · PMID 24587339

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an increasing trendno p-value reported
All outcomes indicated an increasing trend of SK1 mRNA and protein expression levels in cancer tissues.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.