Strikingly, gene set enrichment analysis (GSEA) revealed a highly significant overlap between genes that responded to UNC0638 treatment in HoxA9/Meis1 and those that responded to 4OHT withdrawal in HoxA9-ER/Meis1 cells ( Fig. 4B,C ).
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
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