An enrichment analysis based on functional annotation for proteins using the bioinformatics database DAVID ( Huang et al., 2009a ; Huang et al., 2009b ) revealed a highly significant enrichment for proteins associated with the spliceosome and RNA splicing in the cytoplasmic and/or nucleolar fractions upon knockdown of USPL1 [corrected P -value (Benjamini): <1×10 −10 ; supplementary material Table S2 ].
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A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.
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