Pleiotropic effect of common variants at ABO Glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme.

Confirmatory genotyping in the 2nd stage By genotyping of these associated SNPs using a custom BeadChip (Illumina) in a different sample population of 1,671 individuals from the Yamagata cohort, we successfully confirmed all these associations at highly significant levels ranging from p = 6.58×10 −11 (rs500498) to 1.33×10 −21 (rs8176746) for P-LIP and from 2.96×10 −10 (rs2073824) to 8.34×10 −39 (rs495828) for ACE in 9q32, and also from 1.13×10 −29 (rs4461142) to 5.21×10 −107 (rs4362) for ACE in 17q23.2, as listed in Tables 1 and 2 .

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