The two predicted proteins return highly significant expectancy of 10 −31 and 10 −18 , respectively, when run with HMMer ( Eddy, 1998 ) against the phosphoribosyl-transferase profile PF00156 from Pfam ( Finn et al., 2008 ).
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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.
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